Unprecedented changes in vascular surgery practice over the last twenty years have yielded the endovascular revolution. In the course of such an era, we contemplated that gene therapy would conquest. Nevertheless after phase three human gene trials and more than three billion euro squandered globally on research and development, all that we have attained is that we are remote from any ground breaking clinical outcome. Equally the new kid on the block, cultured stem cell therapy benefits are short lived, costly to set up and we are a decade away from human relevance.
Cardiovascular Anti-Aging programmes are the contemporary frontier in functional metabolic vascular medicine with a novel science of nutrigenomics, in its entirety. Despite this surge in cardiovascular anti-aging practice and escalating credibility, we remain deficient in our knowledge of this field.
This new era of metabolic vascular nutrigenomics harnesses our inherent ability to modulate the interface between specialised gene receptors and bioavailable nutrients in what's recently labelled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimise mitochondrial function and thereby achieve the ultimate cardiovascular cure.
Nevertheless, near imminent glimpse of nutrigenomics that modulate the activity of SIRT enzymes and have the power to master regulators of survival during stress and extend life span will strike our shelves in next to no time.
No doubt, future generations accustomed to living past 100 years will gaze back at our present methodology for vascular intervention as primitive relics of a bygone era. Those who are currently eager to pop a pill and live to 130 years may have been born about half a century ahead of time.
Two third of American's patients are in quest of alternative methods for managing of their diseases. What's more, 50% do not dispense their prescription for fear of concealed side effects. On the other hand, emerging data demonstrates that the number of patients with congestive heart failure has quadrupled over the last decade and there is mounting evidence which links this exponential rise to depleting Coenzyme Q10levels. The discovery of Coenzyme Q10 earned its finder the 1977 Nobel prize; It is a crucial factor in the production of ATP for heart muscle, which acquires 65% of its energy from fat.
More recently, the 2009 Nobel Prize in Medicine was awarded for the discovery that individuals with shorter telomeres have nearly triple the cardiovascular mortality rate of people with longer telomeres and that long-term endurance exercise training has proven protective effects on the arterial wall by activating telomerase and thereby reducing telomere shortening .
Major studies of "cardiovascular free" centenarians delineated that low sugar and low insulin are consistent finding in such individuals. The level of insulin sensitivity of the cell is one of the most crucial markers of lifespan. Insulin is a catabolic inflammatory hormone in the body and a pro-aging reversible factor. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular anti-aging.
Moreover, the contemporary management of type 2 diabetics has been subject to scrutiny and potentially raises some ethical dilemmas. Although the patient might appear to have a need for insulin therapy, the introduction of insulin in the context of severe insulin resistance may lead to hyperinsulinaemia and consequently accelerate their metabolic vascular derangement, resulting in high morbidity and mortality! Right now diabetics can be cured through metabolic vascular intermediaries' nutrigenomics and patients can be weaned off their medication. In addition, in the context of the deranged metabolic milieu that exists for diabetic patients, they fair poorly with beta blockers, diuretics and statins and may require doubling the dose of potent antiplatelets to achieve a therapeutic effect.
Insulin resistance and hyperglycaemia are culprits in the development vascular diseases in two thirds of the population and can be reversed through Cardiovascular Anti-Aging programmes. These programmes consist of achievable lifestyle adjustments with caloric restriction , 12 hours fasting from 6pm to 6 am, 30 minutes daily endurance exercise and functional metabolic vascular medicine with nutrigenomics.
These are methods and techniques that we must master in our present and future practice. The vascular community must expand on its history of revolution and redeem ourselves from the effortless fashion of prescription cardiovascular drugs or ingenuous vascular intervention.